We provide biostatistical support that is readily available to CFAR investigators and to other CFAR Cores. In addition to making strategic contributions to the CFAR’s scientific dialog, we provide statistical consulting services that range from brief professional consultations to invention of new statistical methods. We collaborate on the framing of hypotheses and on the development of study designs, grant applications, journal articles and presentations, selection of statistical methods, performance of statistical computations and interpretive analyses, and research database management consultation and support.
The Biostatistics Core brings together CFAR investigators and professional biostatisticians who possess specialized expertise needed for CFAR research projects. We promote opportunities for faculty and students in the statistical sciences at UNC to participate in HIV/AIDS-related research and become members of the CFAR. The participating faculty of the Biostatistics Department forms an important component of the Biostatistics Core.
We also promote training opportunities for CFAR investigators who are interested in the application of best statistical methods, and provide training opportunities for students and fellows who are assisting in AIDS-related studies. We recommend that investigators contact the Biostatistics Core in the earliest stage of new research efforts and well in advance of deadlines for grant applications, abstract submissions and protocol development.
Please contact the CFAR Biostatistics Core with new requests by e-mailing us at CFARbios@bios.unc.edu.
The goal of the Biostatistics Core is to support and enhance AIDS research of the UNC CFAR. We will accomplish these goals with the following Aims:
Provide a broad spectrum of collaborative biostatistical services
Develop, implement, and disseminate innovative statistical methods for HIV/AIDS research
Support priority CFAR initiatives and goals
Promote CFAR research within UNC, foster inter-CFAR collaborations, and support HIV/AIDS research networks
Provide biostatistical training, mentoring, and education
Engage in evaluation and strategic planning
By accomplishing these Aims the Biostatistics Core will continue to provide key statistical support for the UNC CFAR, ensuring sound statistical design, conduct, and analysis of research leading to a deeper understanding of the HIV epidemic.
Michael Hudgens, Ph.D.
Dr. Hudgens is a Professor in the Department of Biostatistics at the University of North Carolina at Chapel Hill and is Director of the Biostatistics Core of the UNC Center for AIDS Research. He has extensive experience in collaborative research and statistical methodology development related to studies of infectious diseases and vaccines, with an emphasis on HIV. Dr. Hudgens has co-authored over 100 peer-reviewed papers in leading statistical journals such as Biometrika, Biometrics, JASA, and JRSS-B as well as top-tier biomedical journals such as the New England Journal of Medicine, Lancet, and Nature, and currently serves as an Associate Editor for Biometrics and JASA. He is an elected fellow of the American Statistical Association and has taught multiple graduate level biostatistics courses at UNC. Dr. Hudgens is the principal investigator or co-investigator on several NIH NIAID grants to develop novel statistical methodologies for application to infectious disease studies. He has served as lead statistician on multiple clinical trials sponsored by the NIH and CDC and currently serves on an advisory board to the FDA.
Chapel Hill, NC
Office Phone: 919.966.7253
Stephen R Cole, Ph.D.
Associate Core Director
Dr. Cole is a Professor of Epidemiology at UNC with an interest in quantitative epidemiologic methods. He is Associate Director of the Biostatistics Core of the UNC Center for AIDS Research, as well as Director of the Epidemiology and Biostatistics Core of the CFAR Network of Integrated Clinical Systems (CNICS). His research focuses on the use of structural models to explore the causal effect of antiretroviral therapies on HIV disease progression, and direct and indirect causal effects of alcohol intake on HIV acquisition. He is also a member of a Causal Inference Research Group (CIRG) at UNC.
Chapel Hill, NC
Office Phone: 919-966-7415
Katie Mollan, M.S.
Core Manager / Senior Biostatistician
Katie Mollan is a senior biostatistician at the UNC CFAR with over 10 years of HIV research experience. Her collaborative research background spans a breadth of topics in HIV/AIDS, including analysis of large randomized clinical trials, antiretroviral efficacy, psychiatric complications, adherence, drug resistance, pharmacokinetics, HIV testing, and SHIV vaccine development. Ms. Mollan has provided statistical support for grant proposals, HIV network proposals, protocol development, case report forms, database structure, data safety monitoring, statistical analyses, conference presentations, and manuscript preparation. Ms. Mollan has co-authored articles in several medical journals, including Annals of Internal Medicine, Journal of Infectious Diseases, Clinical Infectious Diseases, and the New England Journal of Medicine.
3126 McGavran-Greenberg Hall
Chapel Hill, NC
Office Phone: 919-966-8421
Fei Zou, Ph.D.
Dr. Zou is a Professor in the Department of Biostatistics and the Department of Genetics at the University of North Carolina at Chapel Hill. Her research interest is in the development of theoretical methodologies appropriate for interpretation of high-dimensional genetics and genomics data. She is highly experienced in gene expression data analysis, genome wide association (GWA) mapping, and next generation sequencing data analysis. She is also experienced in designing clinical trials, and analysis of complex observational data.
4115D McGavran-Greenberg Hall
Chapel Hill, NC
Office Phone: 919-843-4822
Ilana Trumble, B.S.
Ilana Trumble is a Ph.D. student in the biostatistics department at UNC. She received her B.S. in Applied Mathematics from the University of Colorado, Boulder. Before coming to UNC, she completed a summer research fellowship at Anschutz Medical Campus with University of Colorado Cancer Center analyzing mutation data of kinases.
Sarah Reifeis, B.S.
Sarah Reifeis is a Ph.D. candidate in the biostatistics department at UNC. She received her B.S. in Mathematics from Indiana University. Before coming to UNC she worked for the chemistry department at Indiana University as an undergraduate researcher conducting computational modeling of the HIV-1 capsid. Additionally, she worked for the biology department at Indiana University as a teaching assistant for two years. In her free time she enjoys hiking, scuba diving, and cooking.
Pooja Saha, B.S.P.H.
Pooja Saha is a Ph.D. candidate in the biostatistics department at UNC. She received her B.S.P.H in Biostatistics and B.S. in Mathematics from UNC Chapel Hill as well. Prior to joining CFAR, she worked for UNC School of Dentistry as a graduate research assistant providing statistical support to faculty members and students.
Past Students (2012 Onward)
CFAR Summer Interns
- Orlando Ferrer, B.S. (2017)
- Sumati Sridhar (2017)
Former Biostatistics Graduate Research Assistants [updates circa 2017]
- Pedro Baldoni, M.S. [Doctoral Research & Hispanic Community Health Study]
- Owen Francis, M.S. [Doctoral Research]
- Brian Barkley, M.S. [Doctoral Research]
- Joseph Rigdon, Ph.D. [Stanford Med/Quant Sciences Unit]
- Lu Mao, Ph.D. [University of Wisconsin Madison]
- Amy Richardson, Ph.D. [Google]
- Andrew G. Allmon, B.S. [Doctoral Research, United Therapeutics, UCB]
The UNC CFAR Biostatistics Core offers a range of services to CFAR investigators, including:
-Training and Tutorial Consultation
-Planning and Study Design
-Grant Proposal Support
-Statistical Computation, Derivation, Interpretive Analysis and Publication
-Coordination and Project Management
-Statistical Methods Research and Development
Adimora AA, Cole SR, Eron JJ. US Black Women and Human Immunodeficiency Virus Prevention: Time for New Approaches to Clinical Trials. Clin Infect Dis. 2017 Jul 15;65(2):324-327. PMC pending.
Bengtson AM, Pence BW, Mollan KR, Edwards JK, Moore RD, OʼCleirigh C, Eaton EF, Eron JJ, Kitahata MM, Mathews WC, Crane H, Mugavero MJ. The Relationship Between Efavirenz as Initial Antiretroviral Therapy and Suicidal Thoughts Among HIV-Infected Adults in Routine Care. J Acquir Immune Defic Syndr. 2017 Dec 1;76(4):402-408. PMC5659970.
Cholera R, Pence BW, Bengtson AM, Crane HM, Christopoulos K, Cole SR, Fredericksen R, Gaynes BN, Heine A, Mathews WC, Mimiaga MJ, Moore R, Napravnik S, O’Clerigh C, Safren S, Mugavero MJ. Mind the Gap: Gaps in Antidepressant Treatment, Treatment Adjustments, and Outcomes among Patients in Routine HIV Care in a Multisite U.S. Clinical Cohort. PLoS One. 2017 Jan 26;12(1). PMC5268441.
Cole SR, Edwards JK, Westreich D, Lesko CR, Lau B, Mugavero MJ, Mathews WC, Eron JJ Jr, Greenland S; CNICS Investigators. Estimating multiple time-fixed treatment effects using a semi-Bayes semiparametric marginal structural Cox proportional hazards regression model. Biom J. 2017 Oct 27. [Epub ahead of print]. PMC pending.
Cole SR, Edwards JK, Hall HI, Brookhart MA, Mathews WC, Moore RD, Crane HM, Kitahata MM, Mugavero MJ, Saag MS, Eron JJ; Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) Investigators. Incident AIDS or Death AfterInitiation of Human Immunodeficiency Virus Treatment Regimens Including Raltegravir or Efavirenz Among Adults in the United States. Clin Infect Dis. 2017 Jun 1;64(11):1591-1596. PMC pending.
Davis NL, Wiener J, Juliano JJ, Adair L, Chasela CS, Kayira D, Hudgens MG, van der Horst C, Jamieson DJ, Kourtis AP; Breastfeeding, Antiretrovirals and Nutrition (BAN) Study Team; Breastfeeding, Antiretrovirals and Nutrition (BAN) Study Team. Co-trimoxazole Prophylaxis, Asymptomatic Malaria Parasitemia, and Infectious Morbidity in Human Immunodeficiency Virus-Exposed, Uninfected Infants in Malawi: The BAN Study. Clin Infect Dis. 2017 Aug 15;65(4):575-580. PMC pending.
Dela Peña-Ponce MG, Rodriguez-Nieves J, Bernhardt J, Tuck R, Choudhary N, Mengual M, Mollan KR, Hudgens MG, Peter-Wohl S, De Paris K. Increasing JAK/STAT Signaling Function of Infant CD4(+) T Cells during the First Year of Life. Front Pediatr. 2017 Feb 21;5:15. PMC5318443.
Drozd DR, Saag MS, Westfall AO, Mathews WC, Haubrich R, Boswell SL, Cole SR, Porter D, Kitahata MM, Juday T, Rosenblatt L; CFAR Network of Integrated Clinical Systems (CNICS). Comparative effectiveness of single versus multiple tablet antiretroviral therapy regimens in clinical HIV practice. Medicine (Baltimore). 2017 Apr;96(14). PMC5411186.
Edmonds A, Ludema C, Eron JJ Jr, Cole SR, Adedimeji AA, Cohen MH, Cooper HL, Fischl M, Johnson MO, Krause DD, Merenstein D, Milam J, Wilson TE, Adimora AA. Effects of Health Insurance Interruption on Loss of Hypertension Control in Women With and Women Without HIV. J Womens Health (Larchmt). 2017 Jul 6. [Epub ahead of print]. PMC pending.
Ewing AC, King CC, Wiener JB, Chasela CS, Hudgens MG, Kamwendo D, Tegha G, Hosseinipour MC, Jamieson DJ, Van der Horst C, Kourtis AP. Effects of concurrent exposure to antiretrovirals and cotrimoxazole prophylaxis among HIV-exposed,
uninfected infants. AIDS. 2017 Sep 18. [Epub ahead of print]. PMC pending.
Fatukasi TV, Cole SR, Moore RD, Mathews WC, Edwards JK, Eron JJ; CNICS investigators. Risk factors for delayed antiretroviral therapy initiation among HIV-seropositive patients. PLoS One. 2017 Jul 10;12(7). PMC5507276.
Honeycutt JB, Thayer WO, Baker CE, Ribeiro RM, Lada SM, Cao Y, Cleary RA, Hudgens MG, Richman DD, Garcia JV. HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapy. Nat Med. 2017 May;23(5):638-643. PMC5419854.
Howe CJ, Dulin-Keita A, Cole SR, Hogan JW, Lau B, Moore RD, Mathews WC, Crane HM, Drozd DR, Geng E, Boswell SL, Napravnik S, Eron JJ Jr, Mugavero MJ. Evaluating the Population Impact of Intervening on Specific Targets to Reduce HIV Racial/Ethnic Disparities in Adulthood: a Conceptual and Methodological Framework. Am J Epidemiol. 2017 Jul 13. [Epub ahead of print]. PMC pending.
Jensen K, Dela Pena-Ponce MG, Piatak M Jr, Shoemaker R, Oswald K, Jacobs WR Jr, Fennelly G, Lucero C, Mollan KR, Hudgens MG, Amedee A, Kozlowski PA, Estes JD, Lifson JD, Van Rompay KK, Larsen M, De Paris K. Balancing Trained Immunity with Persistent Immune Activation and the Risk of Simian Immunodeficiency Virus Infection in Infant Macaques Vaccinated with Attenuated Mycobacterium tuberculosis or Mycobacterium bovis BCG Vaccine. Clin Vaccine Immunol. 2017 Jan 5;24(1). PMC5216431.
Kessing CF, Nixon CC, Li C, Tsai P, Takata H, Mousseau G, Ho PT, Honeycutt JB, Fallahi M, Trautmann L, Garcia JV, Valente ST. In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a “Block-and-Lock” Strategy for HIV-1 Treatment. Cell Rep. 2017 Oct 17;21(3):600-611. PMC5653276.
Lee JS, Cole SR, Richardson DB, Dittmer DP, Miller WC, Moore RD, Kitahata M, Mathews C, Mayer K, Geng E, Achenbach CJ, Eron JJ Jr; Center for AIDS Research Network of Integrated Clinical Systems. Incomplete viral suppression and mortality in HIV patients after antiretroviral therapy initiation. AIDS. 2017 Sep 10;31(14):1989-1997. PMC pending.
Lee SK, Zhou S, Baldoni PL, Speilvogel E, Archin NM, Hudgens MG, Margolis DM, Swanstrom R. Quantification of the Latent HIV-1 Reservoir Using Ultra Deep Sequencing and Primer ID in a Viral Outgrowth Assay. J Acquir Immune Defic Syndr. 2017 Feb 1;74(2):221-228. PMC5233602.
Lesko CR, Buchanan AL, Westreich D, Edwards JK, Hudgens MG, Cole SR. Generalizing Study Results: A Potential Outcomes Perspective. Epidemiology. 2017 Jul;28(4):553-561. PMC5466356.
Lesko CR, Edwards JK, Cole SR, Moore RD, Lau B. When to Censor? Am J Epidemiol. 2017 Aug 11. [Epub ahead of print]. PMC pending.
Lesko CR, Todd JV, Cole SR, Edmonds A, Pence BW, Edwards JK, Mack WJ, Bacchetti P, Rubtsova A, Gange SJ, Adimora AA; WIHS Investigators. Mortality under plausible interventions on antiretroviral treatment and depression in HIV-infected women: an application of the parametric g-formula. Ann Epidemiol. 2017 Sep 5. pii: S1047-2797(16)30348-9. [Epub ahead of print]. PMC pending.
Ludema C, Cole SR, Eron JJ Jr, Holmes GM, Anastos K, Cocohoba J, Cohen MH, Cooper HLF, Golub ET, Kassaye S, Konkle-Parker D, Metsch L, Milam J, Wilson TE, Adimora AA. Health Insurance Type and Control of Hypertension Among US Women Living With and Without HIV Infection in the Women’s Interagency HIV Study. Am J Hypertens. 2017 Jun 1;30(6):594-601. PMC pending.
Mollan KR, Tierney C, Hellwege JN, Eron JJ, Hudgens MG, Gulick RM, Haubrich R, Sax PE, Campbell TB, Daar ES, Robertson KR, Ventura D, Ma Q, Edwards DRV, Haas DW; AIDS Clinical Trials Group. Race/Ethnicity and the Pharmacogenetics of Reported Suicidality With Efavirenz Among Clinical Trials Participants. J Infect Dis. 2017 Sep 1;216(5):554-564. PMC pending.
O’Donnell JK, Gaynes BN, Cole SR, Edmonds A, Thielman NM, Quinlivan EB, Heine A, Modi R, Pence BW. Stressful and traumatic life events as disruptors to antiretroviral therapy adherence. AIDS Care. 2017 Nov;29(11):1378-1385. PMC pending.
Phillips B, Fouda GG, Eudailey J, Pollara J, Curtis AD 2nd, Kunz E, Dennis M, Shen X, Bay C, Hudgens M, Pickup D, Alam SM, Ardeshir A, Kozlowski PA, Van Rompay KKA, Ferrari G, Moody MA, Permar S, De Paris K. Impact of Poxvirus Vector Priming, Protein Coadministration, and Vaccine Intervals on HIV gp120 Vaccine-Elicited Antibody Magnitude and Function in Infant Macaques. Clin Vaccine Immunol. 2017 Oct 5;24(10). PMC5629672.
Price JT, Mollan KR, Fuseini NM, Freeman BL, Mulenga HB, Corbett AH, Vwalika B, Stringer JSA. Vaginal progesterone to reduce preterm birth among HIV-infected pregnant women in Zambia: a feasibility study protocol. Pilot Feasibility Stud. 2017 Jul 18;4:21. PMC5516378.
Qin Y, Tang W, Nowacki A, Mollan K, Reifeis SA, Hudgens MG, Wong NS, Li H, Tucker JD, Wei C. Benefits and Potential Harms of Human Immunodeficiency Virus Self-Testing Among Men Who Have Sex With Men in China: An Implementation Perspective. Sex Transm Dis. 2017 Apr;44(4):233-238. PMC5347468.
Richardson A, Hudgens MG, Fine JP, Brookhart MA. Nonparametric binary instrumental variable analysis of competing risks data. Biostatistics. 2017 Jan;18(1):48-61. PMC pending.
Rudolph JE, Cole SR, Edwards JK, Moore R, O’Cleirigh C, Mathews WC, Christopoulos K; Center for AIDS Research Network of Integrated Clinical Systems. At-Risk Alcohol Use Among HIV-Positive Patients and the Completion of Patient-Reported Outcomes. AIDS Behav. 2017 Jun 15. [Epub ahead of print]. PMC pending.
Saag MS, Westfall AO, Cole SR, Mathews WC, Drozd DR, Mayer KH, Burkholder GA, Kitahata M, Maiese EM; CFAR Network of Integrated Clinical Systems (CNICS). Brief Report: Factors Associated With the Selection of Initial Antiretroviral Therapy From 2009 to 2012. J Acquir Immune Defic Syndr. 2017 Jan 1;74(1):60-64. PMC5140679.
SESH Study Group, Tucker JD. Crowdsourcing to promote HIV testing among MSM in China: study protocol for a stepped wedge randomized controlled trial. Trials. 2017 Oct 2;18(1):447. PMC5625620.
Smith ER, Hudgens M, Sheahan AD, Miller WC, Wheeler S, Nelson JA, Dube Q, Van Rie A. Timing of HIV Seroreversion Among HIV-Exposed, Breastfed Infants in Malawi: Type of HIV Rapid Test Matters. Matern Child Health J. 2017 Feb;21(2):248-252. PMC5290052.
Smith ER, Sheahan AD, Heyderman RS, Miller WC, Wheeler S, Hudgens M, Nelson JA, Dube Q, Van Rie A. Performance of HIV Rapid Tests Among Breastfeeding, Malawian Infants. Pediatr Infect Dis J. 2017 Apr;36(4):405-411. PMC pending.
Smith JS, Sanusi B, Swarts A, Faesen M, Levin S, Goeieman B, Ramotshela S, Rakhombe N, Williamson AL, Michelow P, Omar T, Hudgens MG, Firnhaber C. A randomized clinical trial comparing cervical dysplasia treatment with cryotherapy vs loop electrosurgical excision procedure in HIV-seropositive women from Johannesburg, South Africa. Am J Obstet Gynecol. 2017 Aug;217(2):183. PMC pending.
Stoner MCD, Cole SR, Price J, Winston J, Stringer JSA. Timing of initiation of antiretroviral therapy and risk of preterm birth in studies of HIV-infected pregnant women: the role of selection bias. Epidemiology. 2017 Oct 16. [Epub ahead of print]. PMC pending.
Stringer JS, Stoner MC, Kasaro MP, Vwalika B, Cole SR. Preconception ART and preterm birth: real effect or selection bias? Lancet HIV. 2017 Apr;4(4). PMC pending.
Tang W, Mao J, Tang S, Liu C, Mollan K, Cao B, Wong T, Zhang Y, Hudgens M, Qin Y, Han L, Ma B, Yang B, Ma W, Wei C, Tucker JD; SESH Study Group. Disclosure of sexual orientation to health professionals in China: results from an online cross-sectional study. J Int AIDS Soc. 2017 Feb 6;20(1):21416. PMC5467583.
Todd JV, Cole SR, Pence BW, Lesko CR, Bacchetti P, Cohen MH, Feaster DJ, Gange S, Griswold ME, Mack W, Rubtsova A, Wang C, Weedon J, Anastos K, Adimora AA. Effects of Antiretroviral Therapy and Depressive Symptoms on All-Cause Mortality Among HIV-Infected Women. Am J Epidemiol. 2017 May 15;185(10):869-878. PMC5430940.
Trumble IM, Allmon AG, Archin NM, Rigdon J, Francis O, Baldoni PL, Hudgens MG. SLDAssay: A software package and web tool for analyzing limiting dilution assays. J Immunol Methods. 2017 Nov;450:10-16. PMC5595663.
Wahl A, Ho PT, Denton PW, Garrett KL, Hudgens MG, Swartz G, O’Neill C, Veronese F, Kashuba AD, Garcia JV. Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model. Sci Rep. 2017 Feb 1;7:41098. PMC5286499.
Wohl DA, Allmon AG, Evon D, Hurt C, Reifeis SA, Thirumurthy H, Straub B, Edwards A, Mollan KR. Financial Incentives for Adherence to Hepatitis C Virus Clinical Care and Treatment: A Randomized Trial of Two Strategies. Open Forum Infect Dis. 2017 May 5;4(2). PMC5499638.
Wohl DA, Panter AT, Kirby C, Magnus BE, Hudgens MG, Allmon AG, Mollan KR. Estimating HIV Medication Adherence and Persistence: Two Instruments for Clinical and Research Use. AIDS Behav. 2017 Apr 26. [Epub ahead of print]. PMC pending.
Wohl DA, Golin CE, Knight K, Gould M, Carda-Auten J, Groves JS, Napravnik S, Cole SR, White BL, Fogel C, Rosen DL, Mugavaro MJ, Pence BW, Flynn PM. A Randomized Controlled Trial of an Intervention to Maintain Suppression of HIV Viremia Following Prison Release: The imPACT Trial. J Acquir Immune Defic Syndr. 2017 Mar 8. [Epub ahead of print]. PMC pending.
Zadrozny S, Westreich D, Hudgens MG, Chasela C, Jamieson DJ, Martinson F, Zimba C, Tegha G, Hoffman I, Miller WC, Pence BW, King CC, Kourtis AP, Msungama W, van der Horst C; BAN Study Team. Effect of Postnatal HIV Treatment on Clinical Mastitis and Breast Inflammation in HIV-Infected Breast-feeding Women. Paediatr Perinat Epidemiol. 2017 Feb 16. [Epub ahead of print]. PMC pending.
Chibwesha CJ, Ford CE, Mollan KR, Stringer JS. Point-of-Care Virologic Testing to Improve Outcomes of HIV-Infected Children in Zambia: A Clinical Trial Protocol. J Acquir Immune Defic Syndr. 2016 Aug 1;72 Suppl 2:S197-201. PMC5113248.
Clutton G, Xu Y, Baldoni PL, Mollan KR, Kirchherr J, Newhard W, Cox K, Kuruc JD, Kashuba A, Barnard R, Archin N, Gay CL, Hudgens MG, Margolis DM, Goonetilleke N. The differential short- and long-term effects of HIV-1 latency-reversing agents on T cell function. Sci Rep. 2016 Aug 2;6:30749. PMC4969750.
Cottrell ML, Prince HM, Allmon A, Mollan KR, Hudgens MG, Sykes C, White N, Malone S, Dellon ES, Madanick RD, Shaheen NJ, Patterson KB, Kashuba AD. Cervicovaginal and Rectal Fluid as a Surrogate Marker of Antiretroviral Tissue Concentration: Implications for Clinical Trial Design. J Acquir Immune Defic Syndr. 2016 Aug 15;72(5):498-506. PMC4942408
Cottrell ML, Yang KH, Prince HM, Sykes C, White N, Malone S, Dellon ES, Madanick RD, Shaheen NJ, Hudgens MG, Wulff J, Patterson KB, Nelson JA, Kashuba AD. A Translational Pharmacology Approach to Predicting HIV Pre-Exposure Prophylaxis Outcomes in Men and Women Using Tenofovir Disoproxil Fumarate With or Without Emtricitabine. J Infect Dis. 2016 Jul 1;214(1):55-64. PMC4907409
Davis NL, Miller WC, Hudgens MG, Chasela CS, Sichali D, Kayira D, Nelson JA, Fiscus SA, Regha G, Kamwendo DD, Rigdon J, Stringer JS, Juliano JJ, Ellington SR, Kourtis AP, Jamieson DJ, van der Horst C, BAN study team. Maternal and Breastmilk Viral Load: Impacts of Adherence on Peripartum HIV Infections Averted – The Breastfeeding, Antiretrovirals, and Nutrition Study. J Acquir Immune Defic Syndr. 2016 Dec 15; 73 (5): 572-580. PMC5141681.
Dumond JB, Francis O, Cottrell M, Trezza C, Prince HM, Mollan K, Sykes C, Torrice C, White N, Malone S, Wang R, Van Dam C, Patterson KB, Hudgens MG, Sharpless NE, Forrest A. Tenofovir/emtricitabine metabolites and endogenous nucleotide exposures are associated with p16(INK4a) expression in subjects on combination therapy. Antivir Ther. 2016;21(5):441-5. PMC5266614.
Edwards JK, Cole SR, Lesko CR, Mathews WC, Moore RD, Mugavero MJ, Westreich D. An Illustration of Inverse Probability Weighting to Estimate Policy-Relevant Causal Effects. Am J Epidemiol. 2016 Aug 15;184(4):336-44. PMC4983650.
Floris-Moore MA, Mollan K, Wilkin AM, Johnson MA, Kashuba ADM, Wohl DA, Patterson KB, Francis O, Kronk C, Eron JJ. Antiretroviral activity and safety of once-daily etravirine in treatment-naive HIV-infected adults: 48-week results. Antivir Ther. 2016;21(1):55-64.
Jensen K, Nabi R, Van Rompay KK, Robichaux S, Lifson JD, Piatak M Jr, Jacobs WR Jr, Fennelly G, Canfield D, Mollan KR, Hudgens MG, Larsen MH, Amedee AM, Kozlowski PA, De Paris K. Vaccine-Elicited Mucosal and Systemic Antibody Responses Are Associated with Reduced Simian Immunodeficiency Viremia in Infant Rhesus Macaques. J Virol. 2016 Jul 27;90(16):7285-302. PMC4984660.
Lesko CR, Cole SR, Hall HI, Westreich D, Miller WC, Eron JJ, Li J, Mugavero MJ; CNICS Investigators. The effect of antiretroviral therapy on all-cause mortality, generalized to persons diagnosed with HIV in the USA, 2009-11. Int J Epidemiol. 2016 Feb;45(1):140-50. PMC5013889.
Liu C, Mao J, Wong T, Tang W, Tso LS, Tang S, Zhang Y, Zhang W, Qin Y, Chen Z, Ma W, Kang D, Li H, Liao M, Mollan K, Hudgens M, Bayus B, Huang S, Yang B, Wei C, Tucker JD. Comparing the effectiveness of a crowdsourced video and a socialmarketing video in promoting condom use among Chinese men who have sex with men: a study protocol. BMJ Open. 2016 Oct 3;6(10). PMC5073617.
Lodi S, Sharma S, Lundgren JD, Phillips AN, Cole SR, Logan R, Agan BK, Babiker A, Klinker H, Chu H, Law M, Neaton JD, Hernán MA; INSIGHT Strategic Timing of AntiRetroviral Treatment (START) study group. The per-protocol effect of immediate versus deferred antiretroviral therapy initiation. AIDS. 2016 Nov 13;30(17):2659-2663. PMC5339063.
Ludema C, Cole SR, Eron JJ Jr, Edmonds A, Holmes GM, Anastos K, Cocohoba J, Cohen M, Cooper HL, Golub ET, Kassaye S, Konkle-Parker D, Metsch L, Milam J, Wilson TE, Adimora AA. Impact of Health Insurance, ADAP, and Income on HIV Viral Suppression Among US Women in the Women’s Interagency HIV Study, 2006-2009. JAcquir Immune Defic Syndr. 2016 Nov 1;73(3):307-312. PMC5089078.
Maas BM, Francis O, Mollan KR, Lee C, Cottrell ML, Prince HM, Sykes C, Trezza C, Torrice C, White N, Malone S, Hudgens MG, Sharpless NE, Dumond JB. Concentrations of pro-inflammatory cytokines are not associated with senescence marker p16INK4a or predictive of intracellular emtricitabine/tenofovir metabolite and endogenous nucelotide exposures in adults with HIV infection. PLoS One. 2016 Dec 30; 11 (12). PMC5201235.
Nelson CS, Pollara J, Kunz EL, Jeffries TL Jr, Duffy R, Beck C, Stamper L, Wang M, Shen X, Pickup DJ, Staats HF, Hudgens MG, Kepler TB, Montefiori DC, Moody MA, Tomaras GD, Liao HX, Haynes BF, Ferrari G, Fouda GG, Permar SR. Combined HIV-1 Envelope Systemic and Mucosal Immunization of Lactating Rhesus Monkeys Induces a Robust Immunoglobulin A Isotype B Cell Response in Breast Milk. J Virol. 2016 Apr 29;90(10):4951-65. PMC4859715
O’Donnell JK, Gaynes BN, Cole SR, Edmonds A, Thielman NM, Quinlivan EB, Shirey K, Heine AD, Modi R, Pence BW. Ongoing life stressors and suicidal ideation among HIV-infected adults with depression. J Affect Disord. 2016 Jan 15;190:322-8. PMC4685465
Olesen R, Swanson MD, Kovarova M, Nochi T, Chateau M, Honeycutt JB, Long JM, Denton PW, Hudgens MG, Richardson A, Tolstrup M, Østergaard L, Wahl A, Garcia JV. ART influences HIV persistence in the female reproductive tract and cervicovaginal secretions. J Clin Invest. 2016 Mar 1;126(3):892-904. PMC4767352
Rosen DL, Wohl DA, Golin CE, Rigdon J, May J, White BL, Leone PA, Hudgens MG, Bowling JM. Comparing HIV case detection in prison during opt-in vs. opt-out testing policies. J Acquir Immune Defic Syndr. 2016 Mar 1;71(3):e85-8. PMC4752376
Senkomago V, Backes DM, Hudgens MG, Poole C, Meshnick SR, Agot K, Moses S, Snijders PJ, Meijer CJ, Hesselink AT, Schlecht NF, Bailey RC, Smith JS. Higher HPV16 and HPV18 Penile Viral Loads Are Associated With Decreased Human Papillomavirus Clearance in Uncircumcised Kenyan Men. Sex Transm Dis. 2016 Sep;43(9):572-8. PMC4985051.
Shepherd BE, Liu Q, Mercaldo N, Jenkins CA, Lau B, Cole SR, Saag MS, Sterling TR. Comparing results from multiple imputation and dynamic marginal structural models for estimating when to start antiretroviral therapy. Stat Med. 2016 Oct 30;35(24):4335-4351. PMC5048599.
Tang W, Han L, Best J, Zhang Y, Mollan K, Kim J, Liu F, Hudgens M, Bayus B, Terris-Prestholt F, Galler S, Yang L, Peeling R, Volberding P, Ma B, Xu H, Yang B, Huang S, Fenton K, Wei C, Tucker JD. Crowdsourcing HIV Test Promotion Videos: A Noninferiority Randomized Controlled Trial in China. Clin Infect Dis. 2016 Jun 1;62(11):1436-42. PMC4872295
Yanik EL, Achenbach CJ, Gopal S, Coghill AE, Cole SR, Eron JJ, Moore RD, Mathews WC, Drozd DR, Hamdan A, Ballestas ME, Engels EA. Changes in Clinical Context for Kaposi’s Sarcoma and Non-Hodgkin Lymphoma Among People With HIV Infection in the United States. J Clin Oncol. 2016 Sep 20;34(27):3276-83.
Cole SR, Lau B, Eron JJ, Brookhart MA, Kitahata MM, Martin JN, Mathews WC, Mugavero MJ; for the CNICS Research Network. Estimation of the Standardized Risk Difference and Ratio in a Competing Risks Framework: Application to Injection Drug Use and Progression to AIDS After Initiation of Antiretroviral Therapy. Am J Epidemiol. 2015 Feb 15;181(4):238-45. PMC4325676
Davis NL, Barnett EJ, Miller WC, Dow A, Chasela CS, Hudgens MG, Kayira D, Tegha G, Ellington SR, Kourtis AP, van der Horst C, Jamieson DJ, Juliano JJ. Impact of Daily Cotrimoxazole on Clinical Malaria and Asymptomatic Parasitemias in HIV-Exposed, Uninfected Infants. Clin Infect Dis. 2015 Aug 1;61(3):368-74. PMC4542924
Dumond JB, Rigdon J, Collier AC, Mollan K, Tierney C, Aweeka F, Kashuba ADM. Significant Decreases in both Total and Unbound Lopinavir and Amprenavir Exposures during Co-Administration: ACTG Protocol A5143/A5147s Results. J Acquir Immune Defic Syndr. 2015 Dec 15;70(5):510-4. PMC4648657
Edwards JK, Cole SR, Adimora A, Fine J, Martin J, Eron J. Illustration of a measure to combine viral suppression and viral rebound in studies of HIV therapy. J Acquir Immune Defic Syndr. 2015 Feb 1;68(2):241-4. PMC4294958
Edwards JK, Cole SR, Westreich D, Crane H, Eron JJ, Mathews WC, Moore R, Boswell SL, Mugavero MJ. Multiple Imputation to Account for Measurement Error in Marginal Structural Models. Epidemiology 2015 Sep;26(5):645-52. PMC4638124
Edwards JK, Cole SR, Martin JN, Moore R, Mathews WC, Kitahata M, Eron JJ, Saag M, Mugavero MJ, CNICS Investigators. Dynamic Visual Display of Treatment Response in HIV-Infected Adults. Clin Infect Dis 61:e1-4. 2015. PMC4481601.
Edwards JK, Cole SR, Westreich D, Mugavero MJ, Eron JJ, Moore RD, Mathews WC, Hunt P, Williams C, CNICS investigators. Age at Entry into Care, Timing of Antiretroviral Therapy Initiation, and 10-Year Mortality among HIV-Seropositive Adults in the United States. Clin Infect Dis 2015 Oct 1;61(7):1189-95. PMC4560906.
Feinstein L, Edmonds A, Okitolonda V, Cole SR, Van Rie A, Chi BH, Ndjibu P, Lusiama J, Chalachala JL, Behets F. Maternal Combination Antiretroviral Therapy is Associated with Improved Retention of HIV-Exposed Infants in Kinshasa, Democratic Republic of Congo. J Acquir Immune Defic Syndr 2015 Jul 1;69(3):e93-9. PMC4506694.
Firnhaber C, Mao L, Levin S, Faesen M, Lewis DA, Goeieman BJ, Swarts AJ, Rakhombe N, Michelow PM, Williams S, Smith JS. Evaluation of a cervicography-based program to ensure quality of visual inspection of the cervix in HIV-infected women in Johannesburg, South Africa. J Low Genit Tract Dis. 2015 Jan;19(1):7-11. PMC4272220
Flax VL, Adair LS, Allen LH, Shahab-Ferdows S, Hampel D, Chasela CS, Tegha G, Daza EJ, Corbett A, Davis NL, Kamwendo D, Kourtis AP, van der Horst CM, Jamieson DJ, Bentley ME; BAN Study Team. Plasma Micronutrient Concentrations Are Altered by Antiretroviral Therapy and Lipid-Based Nutrient Supplements in Lactating HIV-Infected Malawian Women. J Nutr. 2015 Aug;145(8):1950-7. PMC4516772
Herce ME, Kalanga N, Wroe EB, Keck JW, Chingoli F, Tengatenga L, Gopal S, Phiri A, Mailosi B, Bazile J, Beste JA, Elmore SN, Crocker JT, Rigodon J. Excellent Clinical Outcomes and Retention in Care for Adults with HIV-Associated Kaposi Sarcoma Treated with Systemic Chemotherapy and Integrated Antiretroviral Therapy in Rural Malawi. J Int AIDS Soc 18:19929. 2015. PMC4450240.
King CC, Kourtis AP, Persaud D, Nelson JAE, Ziemniak C, Hudgens MG, Tegha G, Chasela CS, Jamieson DJ, van der Horst CM. Delayed HIV Detection among Infants Exposed to Postnatal ARV Prophylaxis during Breastfeeding. AIDS 2015 Sep 24;29(15):1953-61. PMC4665628
Lesko CR, Cole SR, Miller WC, Westreich D, Eron JJ, Adimora AA, Moore RD, Mathews WC, Martin JN, Drozd DR, Kitahata MM, Edwards JK, Mugavero MJ. Ten-year survival by race/ethnicity and sex among treated, HIV-infected adults in the United States. Clin Infect Dis. 2015 Jun 1;60(11):1700-7. PMC4447784
Nelson JAE, Fokar A, Hudgens MG, Compliment KJ, Hawkins JT, Tegha G, Kamwendo DD, Kayira D, Mofolo IA, Kourtis AP, Jamieson DJ, van der Horst CM, Fiscus SA. Frequent Nevirapine Resistance in Infants Infected by HIV-1 Via Breastfeeding while on Nevirapine Prophylaxis: Results of the BAN Study. AIDS. 2015 Oct 23;29(16):2131-8. PMC4715989
Nevo ON, Lesko C, Colwell B, Ballard C, Cole SR, Mathews WC. Outcomes of Pharmacist Assisted Management of Antiretroviral Therapy in HIV Infected Patients: A Risk-Adjusted Analysis. American Journal of Health-Systems Pharmacy 2015 Sep 1;72(17):1463-70. PMC4877692
Onsomu EO, Abuya BA, Okech IN, Rosen DL, Duren-Winfield V, Simmons AC. Association between domestic violence and HIV serostatus among married and formerly married women in kenya. Health Care Women Int. 2015 Feb; 36(2): 205-228. PMC4312516.
Oxford KL, Dela Pena-Ponce MG, Jensen K, Eberhardt MK, Spinner A, Van Rompay KK, Rigdon J, Mollan KR, Krishnan VV, Hudgens MG, Barry PA, De Paris K. The interplay between immune maturation, age, chronic viral infection and environment. Immun Ageing. 2015 May 9;12:3. PMC4436863
Sellers CJ, Lee H, Chasela C, Kayira D, Soko A, Mofolo I, Ellington S, Hudgens MG, Kourtis AP, King CC, Jamieson DJ, van der Horst C; BAN Study Team. Reducing lost to follow-up in a large clinical trial of prevention of mother-to-child transmission of HIV: The Breastfeeding, Antiretrovirals and Nutrition study experience. Clin Trials. 2015 Apr;12(2):156-65. PMC4355163
Senkomago V, Backes DM, Hudgens MG, Poole C, Agot K, Moses S, Snijders PJ, Meijer CJ, Hesselink AT, Schlecht NF, Bailey RC, Smith JS. Acquisition and persistence of human papillomavirus 16 (HPV-16) and HPV-18 among men with high-HPV viral load infections in a circumcision trial in Kisumu, Kenya. J Infect Dis. 2015 Mar 1;211(5):811-20. PMC4402376
Soriano-Sarabia N, Archin NM, Bateson R, Dahl NP, Crooks AM, Kuruc JD, Garrido C, Margolis DM. Peripheral Vγ9Vδ2 T Cells Are a Novel Reservoir of Latent HIV Infection. PLoS Pathog. 2015 Oct 16;11(10):e1005201. PMC4608739
Tashima KT, Mollan KR, Na L, Gandhi RT, Klingman KL, Fichtenbaum CJ, Andrade A, Johnson VA, Eron JJ, Smeaton L, Haubrich RH. Regimen Selection in the OPTIONS Trial of HIV Salvage Therapy: Drug Resistance, Prior Therapy, and Race-Ethnicity Determine the Degree of Regimen Complexity HIV Clinical Trials. HIV Clinical Trials 2015 Aug;16(4):147-56. PMC4640927.
Vardhanabhuti S, Taiwo B, Kuritzkes DR, Eron JJ,Jr, Bosch RJ. Phylogenetic Evidence of HIV-1 Sequence Evolution in Subjects with Persistent Low-Level Viraemia. Antivir Ther 20:73-76. 2015. PMC4185268.
Vielot N, Hudgens MG, Mugo N, Chitwa M, Kimani J, Smith J. The Role of Chlamydia trachomatis in High-Risk Human Papillomavirus Persistence Among Female Sex Workers in Nairobi, Kenya. Sex Transm Dis. 2015 Jun;42(6):305-11.PMC4435827
White BL, Golin CE, Grodensky CA, Kiziah CN, Richardson A, Hudgens MG, Wohl DA, Kaplan AH. Effect of Directly Observed Antiretroviral Therapy Compared to Self-Administered Antiretroviral Therapy on Adherence and Virological Outcomes among HIV-Infected Prisoners: A Randomized Controlled Pilot Study. AIDS Behav. 2015 Jan;19(1):128-36. PMC4303492
Zhou S, Jones C, Mieczkowski P, Swanstrom R. Primer ID Validates Template Sampling Depth and Greatly Reduces the Error Rate of Next Generation Sequencing of HIV-1 Genomic RNA Populations. J Virol 2015 Aug;89(16):8540-55. PMC4524263.
Belenky NM, Cole SR, Pence BW, Itemba D, Maro V, Whetten K. Depressive symptoms, HIV medication adherence, and HIV clinical outcomes in Tanzania: a prospective, observational study. PLoS One. 2014 May 5;9(5):e95469. PMC4010413
Corbett AH, Kayira D, White NR, Davis NL, Kourtis AP, Chasela C, Martinson F, Phiri G, Musisi B, Kamwendo D, Hudgens MG, Hosseinipour MC, Nelson JA, Ellington SR, Jamieson DJ, van der Horst C, Kashuba A; the BAN Study Team. Antiretroviral pharmacokinetics in mothers and breastfeeding infants from 6 to 24 weeks post partum: results of the BAN Study. Antivir Ther. 2014;19(6):587-95. PMC4110187
Davis NL, Miller WC, Hudgens MG, Chasela CS, Sinchali D, Kayira D, Nelson JAE, Stringer JSA, Ellington SR, Kourtis AP, Jamieson DJ, van der Horst C. Adherence to extended postpartum antiretrovirals is associated with decreased breast milk HIV-1 transmission. AIDS, 2014 Nov 28; 28(18), 2739-2749. PMC4397579.
Denton PW, Long JM, Wietgrefe SW, Sykes C, Spagnuolo RA, Snyder OD, Perkey K, Archin NM, Choudhary SK, Yang K, Hudgens MG, Pastan I, Haase AT, Kashuba AD, Berger EA, Margolis DM, Garcia JV. Targeted Cytotoxic Therapy Kills Persisting HIV Infected Cells During ART. PLoS Pathog. 2014 Jan;10(1):e1003872. PMC3887103
Edwards JK, Cole SR, Westreich D, Moore R, Mathews C, Geng E, Eron JJ, Mugavero MJ; CNICS Research Network. Loss to clinic and five-year mortality among HIV-infected antiretroviral therapy initiators. PLoS One. 2014 Jul 10;9(7):e102305. PMC4092142
Feinstein L, Edmonds A, Chalachala JL, Okitolonda V, Lusiama J, Van Rie A, Chi BH, Cole SR, Behets F. Temporal Changes in the Outcomes of HIV-Exposed Infants in Kinshasa, Democratic Republic of Congo during a Period of Rapidly Evolving Guidelines for Care (2007-2013). AIDS 28 Suppl 3:S301-11. 2014. PMID:24991903. PMCID: PMC4600322.
Gopal S, Patel MR, Achenbach CJ, Yanik EL, Cole SR, Napravnik S, Burkholder GA, Mathews WC, Rodriguez B, Deeks SG, Mayer KH, Moore RD, Kitahata MM, Richards KL, Eron JJ. Lymphoma immune reconstitution inflammatory syndrome in the center for AIDS research network of integrated clinical systems cohort. Clin Infect Dis. 2014 Jul 15;59(2):279-86. PMC4102912
Howe CJ, Cole SR, Napravnik S, Kaufman JS, Adimora AA, Elston B, Eron JJ Jr, Mugavero MJ. The role of at-risk alcohol/drug use and treatment in appointment attendance and virologic suppression among HIV(+) African Americans. AIDS Res Hum Retroviruses. 2014 Mar;30(3):233-40. PMC3938941
Howe CJ, Napravnik S, Cole SR, Kaufman JS, Adimora AA, Elston B, Eron JJ Jr, Mugavero MJ. African American race and HIV virological suppression: beyond disparities in clinic attendance. Am J Epidemiol. 2014 Jun 15;179(12):1484-92. PMC4051874
Huang Y, Abler L, Pan S, Henderson GE, Wang X, Yao X, Parish WL. Population-based sexual behavior surveys in china: liuzhou compared with other prefectural cities. AIDS Behav. 2014 Feb;18 Suppl 2:118-25. PMC3943943
Jabara CB, Hu F, Mollan K, Williford SE, Menezes P, Yang Y, Eron JJ, Fried MW, Hudgens M, Jones CD, Swanstrom R, Lemon SM. Hepatitis C virus NS3 sequence diversity and antiviral resistance-associated variant frequency in HCV/HIV coinfection. Antimicrob Agents Chemother. 2014 Oct;58(10):6079-92. PMC4187920
Mollan KR, Smurzynski M, Eron JJ, Daar ES, Campbell TB, Sax PE, Gulick RM, Na L, O’Keefe L, Robertson KR, Tierney C. Association Between Efavirenz as Initial Therapy for HIV-1 Infection and Increased Risk for Suicidal Ideation or Attempted or Completed Suicide: An Analysis of Trial Data. Ann Intern Med. 2014 Jul 1;161(1):1-10.
Mugavero MJ, Westfall AO, Cole SR, Geng EH, Crane HM, Kitahata MM, Mathews WC, Napravnik S, Eron JJ, Moore RD, Keruly JC, Mayer KH, Giordano TP, Raper JL; Centers for AIDS Research Network of Integrated Clinical Systems (CNICS). Beyond Core Indicators of Retention in HIV Care: Missed Clinic Visits Are Independently Associated With All-Cause Mortality. Clin Infect Dis. 2014 Nov 15;59(10):1471-9. PMC4215067
Nelson JA, Hawkins JT, Schanz M, Mollan K, Miller MB, Schmitz JL, Fiscus SA. Comparison of the Gen-Probe Aptima HIV-1 and Abbott HIV-1 qualitative assays with the Roche Amplicor HIV-1 DNA assay for early infant diagnosis using dried blood spots. J Clin Virol. 2014 Aug;60(4):418-21. PMC4077672
Nicol MR, Fedoriw Y, Mathews M, Prince HM, Patterson KB, Geller E, Mollan K, Mathews S, Kroetz DL, Kashuba AD. Expression of six drug transporters in vaginal, cervical, and colorectal tissues: Implications for drug disposition in HIV prevention. J Clin Pharmacol. 2014 May;54(5):574-83. PMC4061289
Rahangdale L, Richardson A, Carda-Auten J, Adams R, Grodensky C. Provider Attitudes toward Discussing Fertility Intentions with HIV-Infected Women and Serodiscordant Couples in the USA. J AIDS Clin Res. 2014 May 13;5(6):1000307. PMC4160891
Rosenberg NE, van Lettow M, Tweya H, Kapito-Tembo A, Bourdon CM, Cataldo F, Chiwaula L, Sampathkumar V, Trapence C, Kayoyo V, Kasende F, Kaunda B, Speight C, Schouten E, Eliya M, Hosseinipour M, Phiri S; PURE Malawi Consortium. Improving PMTCT uptake and retention services through novel approaches in peer-based family-supported care in the clinic and community: a 3-arm cluster randomized trial (PURE Malawi). J Acquir Immune Defic Syndr. 2014 Nov 1;67 Suppl 2:S114-9. PMC4197136.
Rositch AF, Mao L, Hudgens MG, Moses S, Agot K, Backes DM, Nyagaya E, Snijders PJF, Meijer CJL, Bailey RC, Smith JS. Risk of HIV acquisition among circumcised and uncircumcised young men with penile HPV infection. AIDS. 2014 28(5):745-52. PMC4074250
Smith KY, Tierney C, Mollan K, Venuto CS, Budhathoki C, Ma Q, Morse GD, Sax P, Katzenstein D, Godfrey C, Fischl M, Daar ES, Collier AC; ACTG 5202 Study Team. Outcomes by Sex following Treatment Initiation with Atazanavir plus Ritonavir or Efavirenz with Abacavir/Lamivudine or Tenofovir/Emtricitabine. Clin Infect Dis. 2014 Feb;58(4):555-63. PMC3905755
Venuto CS, Mollan K, Ma Q, Daar ES, Sax PE, Fischl M, Collier AC, Smith KY, Tierney C, Morse GD; on behalf of the AIDS Clinical Trials Group Study A5202 Team. Sex differences in atazanavir pharmacokinetics and associations with time to clinical events: AIDS Clinical Trials Group Study A5202. J Antimicrob Chemother. 2014 Dec;69(12):3300-10. PMC4228779
Widen EM, Bentley ME, Kayira D, Chasela CS, Daza EJ, Kacheche ZK, Tegha G, Jamieson DJ, Kourtis AP, van der Horst CM, Allen LH, Shahab-Ferdows S, Adair LS; BAN Study Team. Changes in soluble transferrin receptor and hemoglobin concentrations in Malawian mothers are associated with those values in their exclusively breastfed, HIV-exposed infants. J Nutr. 2014 Mar;144(3):367-74. PMC3927549.
Widman L, Choukas-Bradley S, Helms SW, Golin CE, Prinstein MJ. Sexual Communication Between Early Adolescents and Their Dating Partners, Parents, and Best Friends. J Sex Res. 2014;51(7):731-41. PMC4063897
Yanik EL, Napravnik S, Cole SR, Achenbach CJ, Gopal S, Dittmer DP, Olshan AF, Kitahata MM, Mugavero MJ, Saag M, Moore RD, Mathews WC, Hunt P, Eron JJ. Relationship of immunologic response to antiretroviral therapy with non-AIDS defining cancer incidence. AIDS. 2014 Apr 24;28(7):979-87. PMC4040952
Firnhaber CS, Mayisela N, Mao L, Williams S, Swarts A, Faesen M, Levin S, Michelow P, Omar T, Hudgens MG, Williamson AL, Allan B, Lewis D, Smith JS. Validation of cervical cancer screening methods in HIV positive women from Johannesburg, South Africa. PLoS ONE. 2013; 8(1):e53494. PMC3543403
Flax VL, Bentley ME, Chasela CS, Kayira D, Hudgens MG, Kacheche KZ, Chavula C, Kourtis AP, Jamieson DJ, van der Horst CM, Adair LS. Lipid-based nutrient supplements are feasible as a breastmilk replacement for HIV-exposed infants from 24 to 48 weeks of age. J Nutr. 2013 May;143(5):701-7. PMC3738238.
Hoffman IF, Latkin CA, Kukhareva PV, Malov SV, Batluk JV, Shaboltas AV, Skochilov RV, Sokolov NV, Verevochkin SV, Hudgens MG, Kozlov AP. A Peer-Educator Network HIV Prevention Intervention Among Injection Drug Users: Results of a Randomized Controlled Trial in St. Petersburg, Russia. AIDS Behav. 2013 Sep;17(7):2510-20. PMC3950300
Hudgens MG, Taha TE, Omer SB, Jamieson DJ, Lee H, Mofenson LM, Chasela C, Kourtis AP, Kumwenda N, Ruff A, Bedri A, Jackson JB, Musoke P, Bollinger RC, Gupte N, Thigpen MC, Taylor A, van der Horst C. Pooled individual data analysis of 5 randomized trials of infant nevirapine prophylaxis to prevent breast-milk HIV-1 transmission. Clin Infect Dis. 2013 Jan;56(1):131-9. PMCID: PMC3518881.
Patterson KB, Dumond JB, Prince HA, Jenkins A, Scarsi KK, Wang R, Malone S, Hudgens MG, Kashuba ADM. Protein binding of lopinavir and ritonavir during 4 phases of pregnancy: implications for treatment guidelines. J Acquir Immune Defic Syndr. 2013 May; 63(1):51-8. PMC3625477
Ping LH, Joseph SB, Anderson JA, Abrahams MR, Salazar-Gonzalez JF, Kincer LP, Treurnicht FK, Arney L, Ojeda S, Zhang M, Keys J, Potter EL, Chu H, Moore P, Salazar MG, Iyer S, Jabara C, Kirchherr J, Mapanje C, Ngandu N, Seoighe C, Hoffman I, Gao F, Tang Y, Labranche C, Lee B, Saville A, Vermeulen M, Fiscus S, Morris L, Karim SA, Haynes BF, Shaw GM, Korber BT, Hahn BH, Cohen MS, Montefiori D, Williamson C, Swanstrom R; CAPRISA Acute Infection Study and the Center for HIV-AIDS Vaccine Immunology Consortium. Comparison of viral Env proteins from acute and chronic infections with subtype C human immunodeficiency virus type 1 identifies differences in glycosylation and CCR5 utilization and suggests a new strategy for immunogen design. J Virol. 2013 Jul;87(13):7218-33. PMC3700278
Stringer JS, Stinson K, Tih PM, Giganti MJ, Ekouevi DK, Creek TL, Welty TK, Chi BH, Wilfert CM, Shaffer N, Stringer EM, Dabis F, Coetzee D. Measuring coverage in MNCH: population HIV-free survival among children under two years of age in four African countries. PLoS Med. 2013;10(5):e1001424. PMC3646218.
Trott KA, Richardson A, Hudgens MG, Abel K. Immune Activation and Regulation in Simian Immunodeficiency Virus-Plasmodium fragile-Coinfected Rhesus Macaques. J Virol. 2013 Sep;87(17):9523-37. PMC3754117.
Widen EM1, Bentley ME, Kayira D, Chasela CS, Jamieson DJ, Tembo M, Soko A, Kourtis AP, Flax VL, Ellington SR, van der Horst CM, Adair LS; BAN Study team. Maternal weight loss during exclusive breastfeeding is associated with reduced weight and length gain in daughters of HIV-infected Malawian women. J Nutr. 2013 Jul;143(7):1168-75. PMC3681548.
Wohl DA, Dumond JB, Blevins S, Pittard D, Ragan D, Wang R, Massengale K, Walsh K, Floris-Moore M, Eron JJ Jr, Richardson A, Hudgens MG, Kashuba AD. Raltegravir pharmacokinetics in treatment-naive patients is not influenced by race: Results from the Raltegravir Early Therapy in African-Americans Living with HIV (REAL) study. Antimicrob Agents Chemother. 2013 Feb;57(2):784-8. PMC3553727
Chavula C, Long D, Mzembe E, Kayira D, Chasela C, Hudgens MG, Hosseinipour M, King CC, Ellington S, Chigwenembe M, Jamieson DJ, van der Horst C. Stopping the control arm in response to the DSMB: mother’s choice of HIV prophylaxis during breastfeeding in the BAN Study. Contemporary Clinical Trials. 2012 Jan; 33(1):55-9. PMC3253884
Cole SR, Hudgens MG, Tien PC, Anastos K, Kingsley L, Chmiel JS, Jacobson LP. Marginal structural models for case-cohort study designs to estimate the association of antiretroviral therapy initiation with incident AIDS or death. Am J Epidemiol. 175(5):381-90. 2012 PMC3282878.
Denton PW, Nochi T, Lim A, Krisko JF, Martinez-Torres F, Choudhary SK, Wahl A, Olesen R, Zou W, Di Santo JP, Margolis DM, Garcia JV. IL-2 receptor-chain molecule is critical for intestinal T-cell reconstitution in humanized mice. Mucosal Immunology. 2012 Sep;5(5):555-66. PMC3697924
Dow A, Kayira D, Hudgens M, Van Rie A, King CC, Ellington S, Kourtis A, Turner AN, Meshnick S, Kacheche Z, Jamieson DJ, Chasela C, van der Horst C. The effect of cotrimoxazole prophylaxis on adverse health outcomes in HIV-exposed, uninfected infants. The Pediatric Infectious Disease Journal. 31:842-847. 2012 PMC3914144
Flax VL, Bentley ME, Chasela CS, Kayira D, Hudgens MG, Knight RJ, Soko A, Jamieson DJ, van der Horst CM, Adair LS. Use of lipid-based nutrient supplements by HIV-infected Malawian women during lactation has no effect on infant growth from 0 to 24 weeks. J Nutr. 2012 Jul;142(7):1350-6. PMC3374670.
Jamieson DJ, Chasela CS, Hudgens MG, King CC, Kourtis AP, Kayira D, Hosseinipour MC, Kamwendo DD, Ellington SR, Wiener JB, Fiscus SA, Tegha G, Mofolo IA, Sichali DS, Adair LS, Knight RJ, Martinson F, Kacheche Z, Soko A, Hoffman I, van der Horst C; BAN study team. Maternal and infant antiretroviral regimens to prevent postnatal HIV-1 transmission: 48-week follow-up of the BAN randomised controlled trial. Lancet. 2012 Jun; 379(9835):2449-58. PMC3661206.
Nelson JA, Krishnamurthy J, Menezes P, Liu Y, Hudgens MG, Sharpless NE, Eron JJ. Expression of p16INK4a as a biomarker of T-cell aging in HIV-infected patients prior to and during antiretroviral therapy. Aging Cell. 2012 Oct;11(5):916-8. PMC3697001
Rositch AF, Hudgens MG, Backes DM, Moses S, Agot K, Nyagaya E, Snijders PJ, Meijer CJ, Bailey RC, Smith JS. Vaccine-relevant human papillomavirus (HPV) infections and future acquisition of high-risk HPV types in men. J Infect Dis. 2012 Sep 1;206(5):669-77. PMC3491740.
Hoots BE, Hudgens MG, Cole SR, King CC, Klein RS, Mayer KH, Rompalo AM, Sobel JD, Jamieson DJ, Smith JS. Lack of association of herpes simplex virus type 2 seropositivity with the progression of HIV infection in the HERS cohort. Am J Epidemiol.173(7):837-44. 2011 PMC3105280
Ludema C, Cole SR, Poole C, Chu H, Eron JJ. Meta-analysis of randomized trials on the association of prophylactic acyclovir and HIV-1 viral load in individuals co-infected with HSV-2, AIDS. 2011 Jun; 25(10): 1265-9.
Trott KA, Chau JY, Hudgens MG, Fine J, Mfalila CK, Tarara RP, Collins WE, Sullivan J, Luckhart S, Abel K. Evidence for an increased risk of transmission of simian immunodeficiency virus and malaria in a rhesus macaque coinfection model. Journal of Virology. 85(22):11655-63. 2011 PMC3209294
Wang Y, Li B, Pan J, Sengupta S, Emrick CB, Cohen MS, Henderson GE. Factors associated with utilization of a free HIV VCT clinic by female sex workers in Jinan City, Northern China. AIDS and Behavior. 15(4): 702–710. 2011 PMC3140056
Chasela CS, Hudgens MG, Jamieson DJ, Kayira D, Hosseinipour MC, Kourtis AP, Martinson F, Tegha G, Knight RJ, Ahmed YI, Kamwendo DD, Hoffman IF, Ellington SR, Kacheche Z, Soko A, Wiener JB, Fiscus SA, Kazembe P, Mofolo IA, Chigwenembe M, Sichali DS, van der Horst CM; BAN Study Group. Maternal or infant antiretroviral drugs to reduce HIV-1 transmission. New Engl J Med. 362:2316-8. 2010 PMC2790186
Corbett AH, Hosseinipour M, Nyirenda J, Kanyama C, Rezk N, Mkupani P, Sichali D, Tien H, Kashuba A, Mwansambo C, Weigel R, Kazembe P. Pharmacokinetics of generic and trade formulations of lamivudine, stavudine, and nevirapine in HIV-infected Malawian children. Antivir Ther. 15:83-90. 2010 PMCID: PMC2867092
Denton PW, Krisko JF, Powell DA, Mathias M, Kwak YT, Martinez-Torres F, Zou W, Payne DA, Estes JD, Garcia JV. Systemic Administration of Antiretrovirals Prior to Exposure Prevents Rectal and Intravenous HIV-1 Transmission in Humanized BLT Mice. PLoS ONE 5(1): e8829. 2010 PMC2809117
Dumond JB, Vourvahis M, Rezk NL, Patterson KB, Tien HC, White N, Jennings SH, Choi SO, Li J, Wagner MJ, La-Beck NM, Drulak M, Sabo JP, Castles MA, Macgregor TR, Kashuba AD. A phenotype-genotype approach to predicting CYP450 and P-glycoprotein drug interactions with the mixed inhibitor/inducer tipranavir/ritonavir. Clin Pharmacol Therapy. 87:735-42. 2010 PMID: 20147896 PMC2882206
Figueroa JP, Weir SS, Byfield L, Hall A, Cummings SM, Suchindran CM. The challenge of promoting safe sex at sites where persons meet new sex partners in Jamaica: results of the Kingston PLACE cluster randomized controlled trial. Trop Med Int Health. 15: 945-54. 2010 PMID: 20545916
Howe CJ, Cole SR, Napravnik S, Eron JJ. Enrollment, retention, and visit attendance in the University of North Carolina Center for AIDS Research HIV clinical cohort, 2001 – 2007. AIDS Research and Human Retroviruses. 26: 875-81, 2010 PMC2957633
McRae M, Rezk NL, Bridges AS, Corbett AH, Tien HC, Brouwer KL, Kashuba AD. Plasma bile acid concentrations in patients with human immunodeficiency virus infection receiving protease inhibitor therapy: possible implications for hepatotoxicity. Pharmacotherapy. 30:17-24. 2010 PMC2856922
Napravnik S, Cachafeiro A, Stewart P, Eron JJ Jr, Fiscus SA. HIV-1 viral load and phenotypic antiretroviral drug resistance assays based on reverse transcriptase activity in comparison to amplification based HIV-1 RNA and genotypic assays. J Clin Virol. 47:18-22. 2010 PMC2818273
Pungrassami P, Kipp AM, Stewart PW, Chongsuvivatwong V, Strauss RP, Van Rie A. Tuberculosis and AIDS stigma among patients who delay seeking care for tuberculosis symptoms. Int J Tuberc Lung Dis. 14:181-7. 2010 PMC2875178
Seña AC, Hammer JP, Wilson K, Zeveloff A, Gamble J. Feasibility and Acceptability of Door-to-Door Rapid HIV Testing Among Latino Immigrants and Their HIV Risk Factors in North Carolina. AIDS Patient Care STDs. 24:165-173 2010 PMC2864055
Smith JS, Backes DM, Hudgens MG, Bailey RC, Veronesi G, Bogaarts M, Agot K, Ndinya-Achola JO, Maclean I, Agingu W, Meijer CJ, Moses S, Snijders PJ. Prevalence and risk factors of human papillomavirus infection by penile site in uncircumcised Kenyan men. Int J Cancer, 126:572-577. 2010 PMC2795021
Smith JS, Moses S, Hudgens MG, Parker CB, Agot K, Maclean I, Ndinya-Achola JO, Snijders PJF, Meijer CJLM, Bailey RC. Increased risk of HIV acquisition among Kenyan men with human papillomavirus infection. J Infect Dis. 201:1677-85. 2010 PMC2873838
Bengtson A, Pence BW, Eaton EF, Edwards JK, Eron JJ, Mathews WC, Mollan K, Moore RD, O’Cleirigh C, Mugavero MJ. Patterns of Efavirenz Use as First Line Therapy in the United States (US): 1999-2015. 24th Conference on Retroviruses and Opportunistic Infections, Seattle, WA, 2017.
Davis N, Corbett A, Kaullen J, Nelson JAE, Chasela CS, Sichali D, Hudgens MG, Miller WC, Jamieson DJ, Kourtis AP. ARV drug concentrations in breastmilk, viral load, and HIV transmission to the infant. 9th IAS Conference on HIV Science, Paris, France, 2017
Miller W.C., Hoffman I., Rose S., Reifeis S., Hamilton E.L., Lancaster K., Hanscom B., Piwowar-Manning E., Duong B.D., Dumchev K., Djoerban Z., Burns, D., HPTN 074 Study Team. Regional Differences in Injection Drug Use Behaviors– Baseline Results from the HPTN 074 Vanguard HIV Prevention Trial. Poster presentation at IAS 2017 in Paris, France. 23-26 July 2017.
Oramasionwu CU, McNeill T, Hernandez M, Trumble IM, Amanah AY, Carpenter DM, Zule WA. Evaluating the prevalence of high dead space (HDS) syringes in community pharmacies. American Pharmacists Association (APhA) Annual Meeting & Exposition, San Francisco, California, March 2017.
Tang W, Mao J, Tang S, Liu C, Mollan K, Wong T, Zhang T, Hudgens M, Qin Y, Ma B, Liao M, Yang B, Ma W, Kang D, Wei C, Tucker JD.Disclosure of sexual orientation in men who have sex with men. 24th Conference on Retroviruses and Opportunistic Infections, Seattle, WA, 2017.
Wang C, Hudgens MG, Tucker JD, Tang W, Li D, Ling L, Mollan K. Generalizability of an Online Randomized Controlled Trial: an Empirical Analysis. Atlantic Causal Inference Conference, Chapel Hill, North Carolina, May 2017.
Williams B, Ramsey K, Blake J, Southerland J, Mollan K, Webster-Cyriaque J. The effect of oral health on overall self-perceived health in individuals with recent and long-term human immunodeficiency virus (HIV) diagnosis. UNC Dental Research and Review Day, Chapel Hill, North Carolina, 2017.
Davis NL, Wiener J, Ellington S, Chasela C, Kayira D, Hudgens M, van der Horst C, Jamieson D, Kourtis AP. Cotrimoxazole and reduced infectious morbidity in HIV-exposed uninfected infants. 23rd Conference on Retroviruses and Opportunistic Infections, Boston, Massachusetts, 2016.
Phillips B, Fouda G, Eudailey J, Curtis A, Kunz E, Van Rompay K, Moody T, Permar S, De Paris K. Optimization of a pediatric vaccine to prevent breast milk transmission of HIV-1. HIVR4P, Chicago, Illinois, 2016
Tang W, Mao J, Liu C, Wong T, Mollan K, Tang S, Li H, Qin Y, Ma B, Liao M, Yang B, Ma W, Kang D, Wei C, Tucker JD* and SESH study group. Crowdsourcing Condom Promotion Videos: A Non-Inferiority Randomized Controlled Trial in China. 21st International AIDS Society Conference, Durban, South Africa, 2016.
Xu Y, Clutton G, Trumble I, Warren J, Kurac J, Gay C, Crooks A, Chandler V, Adimora A, Deeks S, Margolis D, Hudgens M, Mollan K, Goonetilleke N. Longitudinal assessment of baseline variation in HIV-1 specific T cell responses in HIV-1 infected, durably suppressed individuals. Keystone Symposia, Olympic Valley, California, 2016.
Buchanan AL, Hudgens MG, Cole SR. Generalizing Evidence from Randomized Trials using Inverse Probability of Selection Weights. ENAR, Miami, Florida 2015.
Cottrell ML, Prince HMA, Sykes C, White N, Malone S, Dellon ES, Madanick RD, Shaheen NJ, Patterson KB, Kashuba ADM. Cervicovaginal and Rectal Fluid as a Surrogate Marker of Antiretroviral Tissue Concentration: Implications for Clinical Trial Design. 5th International Workshop on HIV & Women, from Adolescence through Menopause in Seattle, Washington, 2015
Davis N, Miller W, Hudgens M, Chasela C, Sichali D, Nelson J, Rigdon J, Ellington S, Kourtis A, and van der Horst C. ARV adherence associated with reduced breastmilk HIV viral load and HIV transmission. 22nd Conference on Retroviruses and Opportunistic Infections, Seattle, Washington, 2015.
Dumond JB, Francis O, Trezza CR, Messer J, Lee C, Cottrell M, Prince HMA, Mollan K, Sykes C, Torrice C, White N, Malone S, Wang R, Patterson KB, Forrest A, Hudgens MG, Sharpless NE, Kashuba ADM. Association of a Senescence Biomarker with Intracellular Nucleotide Metabolite and Endogenous Nucleotide Exposures in HIV+ Subjects Receiving Tenofovir/Emtricitabine. 16th International Workshop on Clinical Pharmacology of HIV & Hepatitis Therapy, Washington DC, 2015. Poster 34.
Han L, Tang W, Best J, Zhang Y, Kim J, Liu F, Mollan K, Hudgens M, Bayus B, Terris-Prestholt F, Galler S, L. Yang L, Peeling R, Volberding P, Ma B, Yang B, Huang S, Fenton K, Wei C, Tucker J. Crowdsourcing to spur first-time HIV testing among men who have sex with men and transgender individuals in China: a non-inferiority pragmatic randomized controlled trial. International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention, Vancouver, Canada, 2015. TUAD0104.
Jensen K, dela Pena-Ponce MG, Piatak M, Jacobs W, Fennelly G, Mollan K, Hudgens M, Kozlowski P, Amedee A, Estes J, Lifson J, Van Rompay K, Larsen M, De Paris K. The potential of attenuated Mycobacterium tuberculosis or BCG vaccines to enhance oral SIV acquisition in infant macaques. International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention, Vancouver, Canada, 2015. WEAA0106LB.
Jensen K, Van Rompay K, Jacobs W, Fennelly G, Mollan K, Hudgens M, Piatak M, Larsen M, De Paris K. The potential of BCG and HIV-TB vaccines to exacerbate HIV-1 pathogenesis in infants. 22nd Conference on Retroviruses and Opportunistic Infections, Seattle, Washington, 2015.
Joseph S, Kincer L, Bowman N, Menezes P, Robertson K, Anderson A, Loring D, Eron J, Price R, Swanstrom R. HIV-1 Replication in the CNS is Associated With Increased Neurocognitive Impairment. 22nd Conference on Retroviruses and Opportunistic Infections, Seattle, Washington, 2015.
King C, Nelson J, Ziemniak C, Hudgens M, Tegha G, Chasela C, Jamieson D, Persaud D, van der Horst C, Kourtis A. Delayed HIV Detection in Infants Exposed to ARV Prophylaxis During Breastfeeding. 22nd Conference on Retroviruses and Opportunistic Infections, Seattle, Washington, 2015.
Ludema C, Cole SR, Eron JJ, Edmonds A, Holmes GM, Anastos K, Cocohoba J, Cohen MH, Cooper H, Golub ET, Kassaye S, Konkle-Parker D, Metsch L, Milam J, Wilson TE, Adimora AA. Health insurance, ADAP and HIV viral load among women in the Women´s Interagency HIV study, 2006-2009. International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention, Vancouver, Canada, 2015. WEPEC613.
Mollan KR, Tierney C, Eron JJ, Hudgens M, Gulick RM, Haubrich R, Sax PE, Campbell TB, Daar ES, Robertson KR, Ma Q, Haas DW. Composite CYP2B6/CYP2A6 genotype and risk for suicidality among HIV-infected individuals randomly assigned to initiate efavirenz-containing regimens in AIDS Clinical Trials Group studies. International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention, Vancouver, Canada, 2015. TUPEB273.
Nelson J, Fokar A, Hudgens M, Compliment K, Tegha G, Kamwendo D, Kourtis A, Jamieson D, van der Horst C, Fiscus S. NVP Resistance in Infants Infected by HIV-1 via Breastfeeding in the BAN Study. 22nd Conference on Retroviruses and Opportunistic Infections, Seattle, Washington, 2015.
Buchanan AL, Hudgens MG. Generalizing Evidence from Randomized Trials using Inverse Probability of Selection Weights. Atlantic Causal Inference Conference, Providence, Rhode Island 2014.
Dumond JB, Trezza CR, Francis O, Prince HMA, Mollan K, Cottrell M, Sykes C, Torrice C, White N, Malone S, Wang R, Patterson KB, Forrest A, Hudgens MG, Sharpless NE, Kashuba ADM. Tenofovir (TFV), Emtricitabine (FTC), Intracellular Metabolite, and Endogenous Nucleotide (EN) Concentrations as a Function of Aging in HIV+ Subjects. 20th International AIDS Conference, Melbourne, Australia 2014. THPDB0105.
Cottrell ML, Prince HMA, Sykes C, White N, Malone S, Dellon ES, Madanick RD, Shaheen NJ, Hudgens M, Wulff, J, Patterson KB, Kashuba ADM. Mucosal Tissues In Women Exhibit Different Concentrations of Endogenous Nucleotides and Intracellular and Extracellular Antiretroviral (ARV) Concentrations: Implications for Preexposure Prophylaxis (PrEP) Development. 20th International AIDS Conference, Melbourne, Australia 2014.
Davis NL, Miller WC, Hudgens MG, Chasela CS, Sichali DS, Kayira D, Kourtis AP, Ellington SR, Jamieson DJ, van der Horst CM. Antiretroviral Adherence Associated with Reduced Breastmilk HIV-1 Transmission: the BAN Study. 21st Conference on Retroviruses and Opportunistic Infections, Boston, Massachusetts, 2014, #880.
Cottrell ML, Prince HMA, Sykes C, White N, Malone S, Dellon ES, Madanick RD, Shaheen NJ, Hudgens M, Wulff, J, Patterson KB, Kashuba ADM. Mucosal Tissue Pharmacokinetics of Maraviroc and Raltegravir in Women: Implications for Chemoprophylaxis. 15th HIV and Hepatitis PK workshop, Washington DC 2014.
Gopal S, Patel M, Achenbach C, Yanik E, Cole S, Napravnik S, Richard K, Eron J, for the CNICS Investigators. Different Immunologic and Virologic Contexts for HIV-Associated Lymphoma in the CNICS Cohort. 21st Conference on Retroviruses and Opportunistic Infections, Boston, MA, March 3-6, 2014.
Honeycutt J, Vincent H, Wahl A, Spagnuolo RA, Swanson M, Gordon K, Garcia JV. In vivo analysis of HIV persistence and immune responses in the brain. 20th International AIDS Conference, Melbourne, Australia 2014. THPE008
Honeycutt J, Wahl A, Foster J, Spagnuolo RA, Garcia JV. In vivo analysis of HIV replication and persistence in the myeloid compartment. 20th International AIDS Conference, Melbourne, Australia 2014. THPE025
Howe CJ, Napravnik S, Cole SR, Kaufman JS, Adimora AA, Elston B, Eron JJ, Mugavero MJ. African American race and HIV virologic suppression beyond disparities in clinic attendance: a causal mediation analysis approach. 18th International Workshop on HIV Observational Databases (IWHOD), Sitges, Spain, March 27-29, 2014.
Mugavero M, Westfall A, Geng E, Cole S, Crane H, Kitahata M, Mathews C, Napravnik S, Raper J, CFAR Network of Integrated Clinical Systems (CNICS). Beyond Core Indicators of Retention in HIV Card: Added Prognostic Value of Missed Clinic Visits. 21st Conference on Retroviruses and Opportunistic Infections, Boston, MA, March 3-6, 2014.
Van Rie A, Sawry S, Richardson A, DeLong S, Mahomed N, Murdoch D, Moultrie H. Low Incidence of TB and Bacille Calmette Guerin Immune Reconstitution Inflammatory Syndrome in South African Children: Results of a Prospective Cohort Study. 20th Conference on Retroviruses and Opportunistic Infections, Atlanta, 2013, #942.
Denton PW, Long J., Archin N, Wietgrefe S, Choudhary S, Sykes C, Yang K, Hudgens M, Pastan I, Berger E, Haase A, Kashuba A, Margolis D, Garcia JV. Destruction of the Residual Active HIV-1 Reservoir by Env-specific Immunotoxin. International AIDS Society Conference, Kuala Lumpur, Malaysia 2013, OA3-3.
Floris-Moore M, Mollan K, Wilkin A, Johnson M, Kashuba A, Wohl DA, Patterson K, Ragan D, Zelasky C, Currin D, Pittard D, Eron J. Antiretroviral Activity and Safety of Once-daily Etravirine in Treatment-naïve HIV-infected Adults. Infectious Disease Week, San Francisco, 2013, #170.
Mollan K, Smurzynski M, Na L, Robertson K, Campbell T, Sax P, Daar E, Eron J, Gulick R, O’Keefe L, Tierney C. Hazard of Suicidality in Patients Randomly Assigned to Efavirenz for Initial Treatment of HIV-1: a Cross-Study Analysis Conducted by the AIDS Clinical Trials Group (ACTG). Infectious Disease Week, San Francisco, 2013. Oral presentation #670.
Wang C. The Epidemiology and Natural History of HIV and Hepatitis C Co-infection in Southern China. 14th International Symposium on Viral Hepatitis and Liver Disease (ISVHLD), Shanghai, June 2012.
Rahangdale L, Richardson A, Adams R, Grodensky C. Providers’ attitudes toward discussing contraception and fertility intentions with HIV-infected women and serodiscordant couples in the U.S. Abstract submitted to CFAR Joint Symposium on HIV Research in Women, Providence, Rhode Island, 2012.
Long D, Hudgens MG. Estimating the effect of interventions to prevent postnatal mother-to-child transmission of HIV. Poster presentation TUPE178. International AIDS Conference, Washington DC, 2012.
Flax VL, Bentley ME, Chasela CS, Kayira D, Hudgens MG, Kacheche Z, Chavula C, Kourtis AP, Jamieson DJ, van der Horst CM, Adair LS for the BAN study group. The growth of HIV-exposed infants in the Breastfeeding, Antiretrovirals, and Nutrition (BAN) study during the first year of life. Nutrition Congress Africa, South Africa, 2012b.
Flax VL, Bentley ME, Chasela C, Kayira D, Hudgens MG, Kacheche Z, Chavula C, Jamieson DJ, van der Horst C, Adair LS. Patterns and predictors of growth in HIV exposed 24-48-week-old Malawians receiving lipid-based nutrient supplements as a breastmilk replacement: results of the BAN study. Experimental Biology, San Diego, 2012a.
Archin N, Liberty A, Kashuba A, Choudhary S, Kuruc J, Hudgens MG, Kearney M, Eron J, Hazuda D, Margolis D. Administration of vorinostat disrupts HIV-1 latency in patients on ART. 19th Conference on Retroviruses and Opportunistic Infections, Seattle, 2012, #157LB.
Feinstein L, Parikh M, Lapika Dimomfu B, Mupenda B, Duvall S, Hudgens MG, Edmonds A, Chalachala JL, Behets F. Should PMTCT programs take into account socioeconomic indicators related to antenatal care seeking behavior? Poster presentation THPE362. International AIDS Conference, Washington DC, 2012.
Adair LS, Jordan-Bell E, Chasela CS, Kayira D, Wiener J, Flax VL, Hudgens MG, Kacheche Z, Tembo M, Ellington SR, Patel KD, Chitsulo P, Jamieson DJ, van der Horst CM, and Bentley ME for the BAN Study Team. Weight status among HIV-infected women in the Breastfeeding, Antiretrovirals, and Nutrition Study. Nutrition Congress Africa, South Africa, 2012.
Dow A, Kayira D, Hudgens MG, Van Rie A, King CC, Ellington S, Kourtis A, Norris Turner A, Meshnick S, Kumwenda J, Kacheche Z, Jamieson DJ, Chasela C, van der Horst C. The effect of cotrimoxazole prophylaxis on adverse health outcomes in HIV-exposed, uninfected infants: results from the BAN study. Publication CDB212, International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention, Rome, Italy, 2011a.
Hudgens MG, Taha T, Omer SB, Jamieson DJ, Lee H, Mofenson LM, Chasela C, Kourtis AP, Kumwenda N, Ruff A, Bedri Kelo A, Jackson B, Musoke P, Bollinger RC, Gupte N, Thigpen MC,Taylor A, Van der Horst C. Pooled analysis of five randomized trials of infant nevirapine prophylaxis to prevent breast-milk HIV-1 transmission. Oral Abstract WELBC03, International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention, Rome, Italy, 2011.
Janakiraman K, Nelson J, Menezes P, Liu Y, Sharpless N, Eron J. Expression of p16INK4a correlates with increasing age and decreased CD4 count in patients on effective ART. Poster TUPE130, International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention, Rome, Italy, 2011.
Patterson K, Dumond J, Prince H, Jenkins A, Scarsi K, Wang R, Malone S, Hudgens M, Kashuba A, Pharmacokinetics of the LPV/r Tablet in HIV-infected Pregnant Women: A Longitudinal Investigation of Protein Bound and Unbound Drug Exposure with Empiric Dosage Adjustment. Poster #645,18th Conference on Retroviruses and Opportunistic Infections, Boston, 2011.
Corbett A, Kayira D, Kashuba A, White N, Kourtis A, Chasela C, Martinson F, Phiri G, Musisi B, Kamwendo D, Hudgens MG, Hosseinipour M, van der Horst C. Pharmacokinetics (PK) of HAART in Mothers and Breastfeeding Infants from 6-24 wks Post Partum. Interscience Conference on Antimicrobial Agents and Chemotherapy, Boston, 2010.
Kayira D and the BAN Study Group. A High-energy, Micronutrient-fortified Supplement Is Effective for Reducing Nutritional Depletion among HIV-infected, Breastfeeding Women: The Breastfeeding, Antiretrovirals, and Nutrition Study. Paper # 838, 17th Conference on Retrovirus and Opportunistic Infections (CROI), San Francisco, CA, February 2010.
Biostatistics Pop-up Clinic
Each Friday at 10:00 A.M. after the Infectious Diseases Conference on the first floor of the Bioinformatics Building.
Biostatistics Core Research Group
Meets bi-monthly on the 1st Wednesday of each month from 9:30-11:00am, rotating with the UCHCC Cohort meeting
The UNC CFAR Biostatistics Core hosts meetings among quantitative researchers interested in HIV research throughout the research triangle area, including CFAR members and quantitative researchers from UNC, FHI 360, and RTI. The BCRG, formed in spring 2013, provides opportunities for research synergy and networking, through cross-discipline discussion of quantitative methods in HIV/AIDS research. Meetings have been regularly attended by researchers from a range of quantitative fields, including biostatistics, epidemiology and pharmacokinetic modeling. Past presentation topics have included pharmacokinetic modeling, meta-analysis, measurement of viral load outcomes, and statistical methods for serial limiting dilution assays.
View upcoming and previous meetings here.
Power and Sample Size Boot Camp
An Overview of Biostatistics
Brief Statistical Safety Checklist
“To consult the statistician after an experiment is finished is often merely to ask him to conduct a post mortem examination. He can perhaps say what the experiment died of.” – R.A. Fisher
This checklist is designed to help review draft manuscripts, statistical reports, or analysis plans
-Objective / hypotheses of the study are clearly stated
-Endpoints are defined, declare endpoints as primary, secondary, and exploratory as appropriate
-Exposures and covariates are defined
-Sample size calculation is explained (if applicable)
-If applicable, randomization and blinding process are explained
-If applicable, interim stopping guidelines are described
-All statistical methods are described (with references as needed)
-Methodological assumptions were reasonably met
-Reasonable considerations were made for:
- missing data or attrition (e.g. loss to follow-up)
- multiple testing or multiple comparisons
- correlation among observations (e.g. longitudinal or clustered data)
- small sample sizes (e.g. n<30)
-Statistical software and version used are stated (e.g. SAS version 9.3, Cary, North Carolina)
-Statistical significance level is declared (e.g. two-sided .05 significance level)
-Clinical trials: trial registration # included (http://www.clinicaltrials.gov)
Results (including text, tables, figures:
-“Avoid nontechnical uses of technical terms in statistics, such as random (which implies a randomizing device), normal, significant, correlations, and sample.” 1
-Number of decimal places reported appropriately reflects measurement precision
-Summaries of variability/spread are provided (e.g. SD, IQR)
-Sample sizes are provided (n=) and missing data are declared when applicable
-Each p-value is accompanied by a graphical display of data, descriptive statistics, or a confidence interval
-Specific p-values are reported, rather than p<0.05
-“Use of the word significant should always be accompanied by a p-value; otherwise, use substantial, considerable, etc.”3
-Figures are clearly explained by a legend and all axes and symbols are appropriately labeled
-“Any distorted effect sizes (e.g. by truncation of y axis) are clearly labeled and justified”3
-Units of measurement are stated
-Discussion conclusions are in agreement with results
-Limitations of the study design or analytic approach are appropriated stated
For more guidance, refer to standard reporting guidelines (e.g. CONSORT, STROBE, PRISMA, STARD)